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Issue 8, 2011
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Liquid forms of pharmaceutical co-crystals: exploring the boundaries of salt formation

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Abstract

We present evidence of hydrogen bond formation, not salt formation, as the driving force in the liquefaction of a solid pharmaceutical in the form of a neutral acid–base complex, as exemplified by the liquid formed from a mixture of the local anesthetic lidocaine with fatty acids; these complexes exist at the boundary between simple eutectics and partially ionised ionic liquids.

Graphical abstract: Liquid forms of pharmaceutical co-crystals: exploring the boundaries of salt formation

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Publication details

The article was received on 18 Oct 2010, accepted on 17 Nov 2010 and first published on 16 Dec 2010


Article type: Communication
DOI: 10.1039/C0CC04485G
Citation: Chem. Commun., 2011,47, 2267-2269
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    Liquid forms of pharmaceutical co-crystals: exploring the boundaries of salt formation

    K. Bica, J. Shamshina, W. L. Hough, D. R. MacFarlane and R. D. Rogers, Chem. Commun., 2011, 47, 2267
    DOI: 10.1039/C0CC04485G

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