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Issue 4, 2011
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Synthetic oligodeoxynucleotide purification by polymerization of failure sequences

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Abstract

Synthetic oligodeoxynucleotide is purified by capping failure sequences with an acrylated phosphoramidite followed by polymerization and product extraction. The method is suitable for large scale oligonucleotide drug purification.

Graphical abstract: Synthetic oligodeoxynucleotide purification by polymerization of failure sequences

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Publication details

The article was received on 12 Oct 2010, accepted on 29 Oct 2010 and first published on 17 Nov 2010


Article type: Communication
DOI: 10.1039/C0CC04374E
Citation: Chem. Commun., 2011,47, 1345-1347
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    Synthetic oligodeoxynucleotide purification by polymerization of failure sequences

    S. Fang, S. Fueangfung, X. Lin, X. Zhang, W. Mai, L. Bi and S. A. Green, Chem. Commun., 2011, 47, 1345
    DOI: 10.1039/C0CC04374E

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