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Issue 9, 2011
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The selective addition of water to C[double bond, length as m-dash]C bonds; enzymes are the best chemists

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Abstract

Water is the liquid of life. Nature has therefore evolved countless enzymes that catalyse the addition of water to C[double bond, length as m-dash]C bonds, isolated or conjugated. These reactions are regio- and enantioselective, they are part of primary metabolism as well as the secondary metabolism. The enzymes that catalyse these reactions (hydratases or hydro-lyases) are applied industrially in selected cases. However, they are not generally used in the laboratory although they outperform all currently available catalytic chemical methodologies. This feature article highlights the potential that hydratases have for chemistry compared to the acid catalysed addition of water.

Graphical abstract: The selective addition of water to C [[double bond, length as m-dash]] C bonds; enzymes are the best chemists

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Publication details

The article was received on 30 Sep 2010, accepted on 13 Dec 2010 and first published on 18 Jan 2011


Article type: Feature Article
DOI: 10.1039/C0CC04153J
Citation: Chem. Commun., 2011,47, 2502-2510
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    The selective addition of water to C[double bond, length as m-dash]C bonds; enzymes are the best chemists

    J. Jin and U. Hanefeld, Chem. Commun., 2011, 47, 2502
    DOI: 10.1039/C0CC04153J

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