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Issue 1, 2011
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Surface-mediated release of a synthetic small-molecule modulator of bacterial quorum sensing: Gradual release enhances activity

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Abstract

We demonstrate an approach to the surface-mediated release of a synthetic N-acylated L-homoserine lactone (AHL) modulator of bacterial quorum sensing (QS). AHL released gradually from thin films of poly(lactide-co-glycolide) (PLG) is shown to activate QS in the model symbiont Vibrio fischeri at levels that exceed those promoted by direct solution-based administration.

Graphical abstract: Surface-mediated release of a synthetic small-molecule modulator of bacterial quorum sensing: Gradual release enhances activity

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Publication details

The article was received on 01 Jul 2010, accepted on 13 Aug 2010 and first published on 09 Sep 2010


Article type: Communication
DOI: 10.1039/C0CC02316G
Citation: Chem. Commun., 2011,47, 370-372
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    Surface-mediated release of a synthetic small-molecule modulator of bacterial quorum sensing: Gradual release enhances activity

    A. S. Breitbach, A. H. Broderick, C. M. Jewell, S. Gunasekaran, Q. Lin, D. M. Lynn and H. E. Blackwell, Chem. Commun., 2011, 47, 370
    DOI: 10.1039/C0CC02316G

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