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Issue 1, 2011
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The natural product hybrid of Syringolin A and Glidobactin A synergizes proteasome inhibition potency with subsite selectivity

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Abstract

The preparation of a Syringolin A/Glidobactin A hybrid (SylA–GlbA) consisting of a SylA macrocycle connected to the GlbA side chain and its potent proteasome targeting of all three proteasomal subsites is reported. The influence of the syrbactin macrocycle moiety on subsite selectivity is demonstrated.

Graphical abstract: The natural product hybrid of Syringolin A and Glidobactin A synergizes proteasome inhibition potency with subsite selectivity

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Publication details

The article was received on 30 Jun 2010, accepted on 17 Aug 2010 and first published on 07 Sep 2010


Article type: Communication
DOI: 10.1039/C0CC02238A
Citation: Chem. Commun., 2011,47, 385-387
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    The natural product hybrid of Syringolin A and Glidobactin A synergizes proteasome inhibition potency with subsite selectivity

    J. Clerc, N. Li, D. Krahn, M. Groll, A. S. Bachmann, B. I. Florea, H. S. Overkleeft and M. Kaiser, Chem. Commun., 2011, 47, 385
    DOI: 10.1039/C0CC02238A

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