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Issue 1, 2011
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An engineered riboswitch as a potential gene-regulatory platform for reducing antibacterial drug resistance

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Abstract

Synthetic riboswitch containing aptamer is constructed in E. coli to regulate the expression of β-lactamase through small molecule–aptamer interactions, which sharply reduces the antibiotic resistance of the engineered bacteria.

Graphical abstract: An engineered riboswitch as a potential gene-regulatory platform for reducing antibacterial drug resistance

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Publication details

The article was received on 16 Apr 2010, accepted on 02 Jun 2010 and first published on 30 Jun 2010


Article type: Communication
DOI: 10.1039/C0CC00980F
Citation: Chem. Commun., 2011,47, 173-175
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    An engineered riboswitch as a potential gene-regulatory platform for reducing antibacterial drug resistance

    X. Feng, L. Liu, X. Duan and S. Wang, Chem. Commun., 2011, 47, 173
    DOI: 10.1039/C0CC00980F

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