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Issue 47, 2011
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Expanding the accessible chemical space by solid phase synthesis of bicyclic homodetic peptides

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Abstract

Norbornapeptides (bicyclo[2.2.1]heptapeptides) and related bicyclic homodetic peptides were prepared by solid-phase peptide synthesis using an orthogonal protection scheme. These conformationally rigid peptides cover an almost pristine area of peptide topological space and adopt globular shapes similar to those of short α-helical peptides.

Graphical abstract: Expanding the accessible chemical space by solid phase synthesis of bicyclic homodetic peptides

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Publication details

The article was received on 15 Sep 2011, accepted on 11 Oct 2011 and first published on 27 Oct 2011


Article type: Communication
DOI: 10.1039/C1CC15704C
Citation: Chem. Commun., 2011,47, 12634-12636
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    Expanding the accessible chemical space by solid phase synthesis of bicyclic homodetic peptides

    M. Bartoloni, R. U. Kadam, J. Schwartz, J. Furrer, T. Darbre and J. Reymond, Chem. Commun., 2011, 47, 12634
    DOI: 10.1039/C1CC15704C

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