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Issue 44, 2011
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Efficient RNA synthesis by in vitrotranscription of a triazole-modified DNA template

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Abstract

A DNA strand containing a triazole phosphodiester mimic is an efficient template for in vitrotranscription. This is the first demonstration of transcription through a heavily modified DNA backbone linkage and it suggests that click-ligated DNA could be useful for the direct synthesis of biologically active RNA and proteins.

Graphical abstract: Efficient RNA synthesis by in vitrotranscription of a triazole-modified DNA template

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Publication details

The article was received on 18 Jul 2011, accepted on 19 Aug 2011 and first published on 30 Sep 2011


Article type: Communication
DOI: 10.1039/C1CC14316F
Citation: Chem. Commun., 2011,47, 12057-12058
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    Efficient RNA synthesis by in vitrotranscription of a triazole-modified DNA template

    A. H. El-Sagheer and T. Brown, Chem. Commun., 2011, 47, 12057
    DOI: 10.1039/C1CC14316F

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