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Issue 28, 2011
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Drug release from hydrazone-containing peptide amphiphiles

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Abstract

Hydrolytically-labile hydrazones in peptide amphiphiles were studied as degradable tethers for release of the drug nabumetone from nanofiber gels. On-resin addition of the novel compound tri-Boc-hydrazido adipic acid to a lysine ε-amine allowed for precise placement of a hydrazide in a peptide sequence.

Graphical abstract: Drug release from hydrazone-containing peptide amphiphiles

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Publication details

The article was received on 02 May 2011, accepted on 27 May 2011 and first published on 15 Jun 2011


Article type: Communication
DOI: 10.1039/C1CC12570B
Citation: Chem. Commun., 2011,47, 7962-7964
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    Drug release from hydrazone-containing peptide amphiphiles

    J. B. Matson and S. I. Stupp, Chem. Commun., 2011, 47, 7962
    DOI: 10.1039/C1CC12570B

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