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Issue 28, 2011
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The effect of neat ionic liquid on the folding of short peptides

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Abstract

Using circular dichroism spectroscopy, we show evidence of unusual folding behaviour for several designed peptides in neat ionic liquid. Helical peptides, AKA2 and Trp-cage, exhibit heat-induced folding, with stable helical structure persisting to 96 °C, whereas the β-hairpin Trpzip4 is destabilized by the neat [C4mpy][Tf2N].

Graphical abstract: The effect of neat ionic liquid on the folding of short peptides

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Publication details

The article was received on 16 Mar 2011, accepted on 02 Jun 2011 and first published on 13 Jun 2011


Article type: Communication
DOI: 10.1039/C1CC11527H
Citation: Chem. Commun., 2011,47, 8007-8009
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    The effect of neat ionic liquid on the folding of short peptides

    J. Lin Huang, M. E. Noss, K. M. Schmidt, L. Murray and M. R. Bunagan, Chem. Commun., 2011, 47, 8007
    DOI: 10.1039/C1CC11527H

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