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Issue 17, 2011
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Pin-point chemical modification of RNA with diverse molecules through the functionality transfer reaction and the copper-catalyzed azidealkyne cycloaddition reaction

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Abstract

The internal modification of RNA has been successfully achieved by the functionality transfer reaction (FTR) and following click chemistry with diverse azide compounds. The benefits of the FTR have been demonstrated by its specificity, rapidity, broad applicability, and procedure simplicity.

Graphical abstract: Pin-point chemical modification of RNA with diverse molecules through the functionality transfer reaction and the copper-catalyzed azide–alkyne cycloaddition reaction

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Publication details

The article was received on 29 Jan 2011, accepted on 04 Mar 2011 and first published on 23 Mar 2011


Article type: Communication
DOI: 10.1039/C1CC10582E
Citation: Chem. Commun., 2011,47, 5004-5006
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    Pin-point chemical modification of RNA with diverse molecules through the functionality transfer reaction and the copper-catalyzed azidealkyne cycloaddition reaction

    K. Onizuka, A. Shibata, Y. Taniguchi and S. Sasaki, Chem. Commun., 2011, 47, 5004
    DOI: 10.1039/C1CC10582E

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