Issue 22, 2011
From the journal:

Chemical Communications

Structure inducing ionic liquids—enhancement of alpha helicity in the Abeta(1–40) peptide from Alzheimer's disease†

Natalie Debeljuh,a   Colin J. Barrow,a   Luke Hendersonb  and  Nolene Byrne*a  

* Corresponding authors

a Institute for Technology Research and Innovation, Deakin University, Geelong, Australia
E-mail: nolene.byrne@deakin.edu.au

b School of Life and Environmental Sciences, Deakin University, Geelong, Australia

Abstract

We have studied the impact of ionic liquid solvents on the structure of the Abeta(1–40) peptide from Alzheimer's disease and found that ionic liquid solvents were able to induce a conformational change in the structure of the Abeta(1–40) peptide. This conformational change impacts the self-assembly of the peptide into amyloid fibrils.

Graphical abstract: Structure inducing ionic liquids—enhancement of alpha helicity in the Abeta(1–40) peptide from Alzheimer's disease

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Article information

DOI
https://doi.org/10.1039/C1CC10377F
Article type
Communication
Submitted
19 Jan 2011
Accepted
14 Apr 2011
First published
06 May 2011

Chem. Commun., 2011,47, 6371-6373

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Structure inducing ionic liquids—enhancement of alpha helicity in the Abeta(1–40) peptide from Alzheimer's disease

N. Debeljuh, C. J. Barrow, L. Henderson and N. Byrne, Chem. Commun., 2011, 47, 6371 DOI: 10.1039/C1CC10377F

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