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Issue 17, 2011
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Positional photocleavage control of DNA-based nanoswitches

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Abstract

DNA-based switches are currently operated by manual solution-phase addition of ‘set-strands’. We demonstrate another operation method—sterically inaccessible ‘set-strands’, released from a surface into solution by spatially controlled photocleavage. This technique will enable microarrays of set-strands to operate many DNA-based switches in self-contained computational and diagnostic devices.

Graphical abstract: Positional photocleavage control of DNA-based nanoswitches

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Publication details

The article was received on 16 Jan 2011, accepted on 07 Feb 2011 and first published on 21 Feb 2011


Article type: Communication
DOI: 10.1039/C1CC10292C
Citation: Chem. Commun., 2011,47, 4905-4907
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    Positional photocleavage control of DNA-based nanoswitches

    A. K. Mok, N. A. Kedzierski, P. N. Chung and P. S. Lukeman, Chem. Commun., 2011, 47, 4905
    DOI: 10.1039/C1CC10292C

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