Issue 13, 2011

Development of a quinoxaline-based fluorescent probe for quantitative estimation of protein binding site polarity

Abstract

The compound 2-[(1E)-2-(1H-pyrrol-2-yl)ethenyl]-quinoxaline (PQX) is a promising fluorescent chromophore for the estimation of protein binding site polarity, due to its full-color solvatochromic fluorescence. A linear relationship was obtained between the peak emission wavenumber and ENT (normalized solvent polarity). The BSA binding site polarity was estimated from the solvatochromic plot.

Graphical abstract: Development of a quinoxaline-based fluorescent probe for quantitative estimation of protein binding site polarity

Supplementary files

Article information

Article type
Communication
Submitted
11 Jan 2011
Accepted
03 Feb 2011
First published
17 Feb 2011

Chem. Commun., 2011,47, 3867-3869

Development of a quinoxaline-based fluorescent probe for quantitative estimation of protein binding site polarity

K. Kudo, A. Momotake, Y. Kanna, Y. Nishimura and T. Arai, Chem. Commun., 2011, 47, 3867 DOI: 10.1039/C1CC10183H

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