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Issue 5, 2011
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A powerful synergistic effect for highly efficient diastereo- and enantioselective phase-transfer catalyzed conjugate additions

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Abstract

An efficient, catalytic, diastereo- and enantioselective conjugate addition of N-(diphenylmethylene)glycine tert-butyl ester to β-aryl substituted enones was realized in the presence of 1 mol% of newly desired dinuclear N-spiro-ammonium salts, affording functionalized α-amino acid derivatives in 57–98% yields with high diastereoselectivity (up to 99 : 1 dr) and enantioselectivity (up to 96.5 : 3.5 er).

Graphical abstract: A powerful synergistic effect for highly efficient diastereo- and enantioselective phase-transfer catalyzed conjugate additions

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Publication details

The article was received on 09 Oct 2010, accepted on 02 Nov 2010 and first published on 29 Nov 2010


Article type: Communication
DOI: 10.1039/C0CC04321D
Citation: Chem. Commun., 2011,47, 1631-1633
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    A powerful synergistic effect for highly efficient diastereo- and enantioselective phase-transfer catalyzed conjugate additions

    M. Hua, L. Wang, H. Cui, J. Nie, X. Zhang and J. Ma, Chem. Commun., 2011, 47, 1631
    DOI: 10.1039/C0CC04321D

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