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Issue 2, 2011
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Quaternarized pdppz: synthesis, DNA-binding and biological studies of a novel dppz derivative that causes cellular death upon light irradiation

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Abstract

The quaternarized pdppz derivative 1 was shown to bind strongly to DNA with concomitant changes in its ground and excited state photophysical properties. Furthermore, the compound also showed rapid cellular uptake, and induced apoptosis upon light irradiation in various cancer cell lines after 24 hours of incubation.

Graphical abstract: Quaternarized pdppz: synthesis, DNA-binding and biological studies of a novel dppz derivative that causes cellular death upon light irradiation

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Publication details

The article was received on 08 Oct 2010, accepted on 02 Nov 2010 and first published on 22 Nov 2010


Article type: Communication
DOI: 10.1039/C0CC04303F
Citation: Chem. Commun., 2011,47, 686-688
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    Quaternarized pdppz: synthesis, DNA-binding and biological studies of a novel dppz derivative that causes cellular death upon light irradiation

    R. B. P. Elmes, M. Erby, S. M. Cloonan, S. J. Quinn, D. C. Williams and T. Gunnlaugsson, Chem. Commun., 2011, 47, 686
    DOI: 10.1039/C0CC04303F

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