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Issue 2, 2011
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Acid-degradable solid-walled microcapsules for pH-responsive burst-release drug delivery

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Abstract

Acid-degradable microcapsules were prepared via an interfacial polymerization. Degradation of the thin wall of the capsules leads to all-or-nothing cargo release. The only byproducts of degradation are acetone, and a non-toxic triamide. Proof-of-concept experiments showed that cargo can be delivered to and released in cells.

Graphical abstract: Acid-degradable solid-walled microcapsules for pH-responsive burst-release drug delivery

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Publication details

The article was received on 01 Oct 2010, accepted on 08 Nov 2010 and first published on 26 Nov 2010


Article type: Communication
DOI: 10.1039/C0CC04190D
Citation: Chem. Commun., 2011,47, 665-667
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    Acid-degradable solid-walled microcapsules for pH-responsive burst-release drug delivery

    K. E. Broaders, S. J. Pastine, S. Grandhe and J. M. J. Fréchet, Chem. Commun., 2011, 47, 665
    DOI: 10.1039/C0CC04190D

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