Issue 9, 2011
From the journal:

Chemical Communications

Solid phase strain promoted “click” modification of DNAvia[3+2]-nitrile oxide–cyclooctyne cycloadditions†

Ishwar Singh*a  and  Frances Heaney*a  

* Corresponding authors

a Department of Chemistry, National University of Ireland, Maynooth, Maynooth, Co. Kildare, Republic of Ireland
E-mail: mary.f.heaney@nuim.ie, ishwar.singh@nuim.ie
Fax: +353 17083815
Tel: +353 17083802

Abstract

Rapid, catalyst free, solid phase modification of DNA by strain promoted cyclooctyne–nitrile oxide click chemistry is reported; the reaction is characterised by mild conditions, occurring in an aqueous environment under atmospheric conditions at room temperature and is complete in 10 minutes.

Graphical abstract: Solid phase strain promoted “click” modification of DNAvia[3+2]-nitrile oxide–cyclooctyne cycloadditions

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Article information

DOI
https://doi.org/10.1039/C0CC03985C
Article type
Communication
Submitted
20 Sep 2010
Accepted
30 Nov 2010
First published
21 Dec 2010

Chem. Commun., 2011,47, 2706-2708

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Solid phase strain promoted “click” modification of DNAvia[3+2]-nitrile oxide–cyclooctyne cycloadditions

I. Singh and F. Heaney, Chem. Commun., 2011, 47, 2706 DOI: 10.1039/C0CC03985C

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