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Issue 9, 2011
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Solid phase strain promoted “click” modification of DNAvia[3+2]-nitrile oxide–cyclooctyne cycloadditions

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Abstract

Rapid, catalyst free, solid phase modification of DNA by strain promoted cyclooctynenitrile oxide click chemistry is reported; the reaction is characterised by mild conditions, occurring in an aqueous environment under atmospheric conditions at room temperature and is complete in 10 minutes.

Graphical abstract: Solid phase strain promoted “click” modification of DNAvia[3+2]-nitrile oxide–cyclooctyne cycloadditions

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Publication details

The article was received on 20 Sep 2010, accepted on 30 Nov 2010 and first published on 21 Dec 2010


Article type: Communication
DOI: 10.1039/C0CC03985C
Citation: Chem. Commun., 2011,47, 2706-2708
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    Solid phase strain promoted “click” modification of DNAvia[3+2]-nitrile oxide–cyclooctyne cycloadditions

    I. Singh and F. Heaney, Chem. Commun., 2011, 47, 2706
    DOI: 10.1039/C0CC03985C

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