Concise synthesis of catechin probes enabling analysis and imaging of EGCg

Atsushi Yoshida; Yasuo Hirooka; Yusuke Sugata; Mariko Nitta; Tamiko Manabe; Shunsuke Ido; Kouki Murakami; Repon Kumer Saha; Takashi Suzuki; Motohiro Ohshima; Akira Yoshida; Kunihiko Itoh; Kosuke Shimizu; Naoto Oku; Takumi Furuta; Tomohiro Asakawa; Toshiyuki Wakimoto; Toshiyuki Kan

doi:10.1039/C0CC03676E

Concise synthesis of catechin probes enabling analysis and imaging of EGCg†

Atsushi Yoshida,^a Yasuo Hirooka,^a Yusuke Sugata,^a Mariko Nitta,^a Tamiko Manabe,^a Shunsuke Ido,^a Kouki Murakami,^a Repon Kumer Saha,^a Takashi Suzuki,^a Motohiro Ohshima,^a Akira Yoshida,^a Kunihiko Itoh,^a Kosuke Shimizu,^a Naoto Oku,^a Takumi Furuta,‡^a Tomohiro Asakawa,^a Toshiyuki Wakimoto §^a and Toshiyuki Kan*^a

Author affiliations

* Corresponding authors

^a School of Pharmaceutical Sciences, University of Shizuoka and Global COE Program, 52-1 Yada, Suruga-ku, Shizuoka-shi, Shizuoka 422-8526, Japan
E-mail: kant@u-shizuoka-ken.ac.jp
Fax: +81 (0)54-264-5746
Tel: +81 (0)54-264-5745

Abstract

A concise synthesis of APDOEGCg (3) was accomplished. Due to the reactivity of its amine group, the compound could be easily converted to the fluorescein probe 21 and immunogen probe 22 efficiently. We then demonstrated the usefulness of the probes for imaging studies and the generation of antibodies.

Chemical Communications

Concise synthesis of catechin probes enabling analysis and imaging of EGCg†

Abstract

Supplementary files

Article information

Download Citation

Permissions

Concise synthesis of catechin probes enabling analysis and imaging of EGCg

Social activity

Search articles by author

Spotlight

Advertisements