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Issue 1, 2011
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DNA–nanoparticle micelles as supramolecular fluorogenic substrates enabling catalytic signal amplification and detection by DNAzyme probes

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Abstract

Catalytic DNA molecules have tremendous potential in propagating detection events vianucleic acid sequence selective signal amplification. However, they suffer from product inhibition limiting their widespread utility. Herein, this limitation is overcome utilizing a novel fluorogenic substrate design consisting of cooperatively assembled DNA–nanoparticle micelles.

Graphical abstract: DNA–nanoparticle micelles as supramolecular fluorogenic substrates enabling catalytic signal amplification and detection by DNAzyme probes

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Publication details

The article was received on 01 Jul 2010, accepted on 12 Aug 2010 and first published on 07 Sep 2010


Article type: Communication
DOI: 10.1039/C0CC02291H
Citation: Chem. Commun., 2011,47, 167-169
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    DNA–nanoparticle micelles as supramolecular fluorogenic substrates enabling catalytic signal amplification and detection by DNAzyme probes

    M. Chien, M. P. Thompson and N. C. Gianneschi, Chem. Commun., 2011, 47, 167
    DOI: 10.1039/C0CC02291H

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