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Issue 1, 2011
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Targeting glycolysis: a fragment based approach towards bifunctional inhibitors of hLDH-5

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Abstract

hLDH-5 has emerged as a promising target for anti-glycolytic cancer chemotherapy. Here we report a first generation of bifunctional inhibitors, which show promising activity against hLDH-5.

Graphical abstract: Targeting glycolysis: a fragment based approach towards bifunctional inhibitors of hLDH-5

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Publication details

The article was received on 28 Apr 2010, accepted on 07 Jul 2010 and first published on 30 Jul 2010


Article type: Communication
DOI: 10.1039/C0CC01166E
Citation: Chem. Commun., 2011,47, 230-232
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    Targeting glycolysis: a fragment based approach towards bifunctional inhibitors of hLDH-5

    A. D. Moorhouse, C. Spiteri, P. Sharma, M. Zloh and J. E. Moses, Chem. Commun., 2011, 47, 230
    DOI: 10.1039/C0CC01166E

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