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Issue 8, 2011
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Tissue imprint imaging by desorption electrospray ionization mass spectrometry

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Abstract

Cross-sections of Myristica malabarica (Lam) seed and mouse brain tissue were imprinted on such ordinary surfaces as printer paper and TLC plates, and successfully imaged by desorption electrospray ionization mass spectrometry (DESI-MS) at 250 μm resolution. Chemical images representing the distribution of the alkaloid malabaricone C in the seed substructures and individual lipids in the substructures of the brain were obtained. Practical implications include analysis of irregular or soft materials, easy recording, transportation and storage of the latent image, and posterior analysis of the samples by different techniques without the requirement of addition of matrices or use of specific types of surfaces.

Graphical abstract: Tissue imprint imaging by desorption electrospray ionization mass spectrometry

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Publication details

The article was received on 17 May 2011, accepted on 18 Jun 2011 and first published on 18 Jul 2011


Article type: Technical Note
DOI: 10.1039/C1AY05295K
Citation: Anal. Methods, 2011,3, 1910-1912
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    Tissue imprint imaging by desorption electrospray ionization mass spectrometry

    D. R. Ifa, A. Srimany, L. S. Eberlin, H. R. Naik, V. Bhat, R. G. Cooks and T. Pradeep, Anal. Methods, 2011, 3, 1910
    DOI: 10.1039/C1AY05295K

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