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Issue 20, 2011
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Optical trapping for the characterization of amyloid-beta aggregation kinetics

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Abstract

Alzheimer's disease (AD) is marked by the accumulation of neuronal plaques from insoluble amyloid-beta (Aβ) peptides. Growing evidence for the role of Aβ oligomers in neuronal cell cytotoxicity and pathogenesis has prompted the development of novel techniques to better understand the early stages of aggregation. Near infrared (NIR) optical trapping was applied to characterize the early stages of Aβ aggregation in the presence of a β-sheet intercalating dye, Congo Red (CR), as the fluorescent marker. The integration of fluorescence analysis with NIR optical trapping has provided a new outlook into the first two hours of Aβ aggregation.

Graphical abstract: Optical trapping for the characterization of amyloid-beta aggregation kinetics

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Publication details

The article was received on 10 Jun 2011, accepted on 02 Aug 2011 and first published on 26 Aug 2011


Article type: Paper
DOI: 10.1039/C1AN15480J
Citation: Analyst, 2011,136, 4164-4167
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    Optical trapping for the characterization of amyloid-beta aggregation kinetics

    A. J. Veloso, H. Yoshikawa, X. R. Cheng, E. Tamiya and K. Kerman, Analyst, 2011, 136, 4164
    DOI: 10.1039/C1AN15480J

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