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Issue 16, 2011
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Using liquid crystals as a readout system in urinary albumin assays

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Abstract

Detecting human serum albumin (HSA) in urine samples is a standard procedure for the diagnosis of kidney problems and the prognosis of patients with chronic kidney diseases (CKDs). In this study, we developed a HSA assay by incorporating a thin layer of liquid crystals (LCs) as a readout system such that the presence of HSA in urine samples can be detected as optical signals. In combination with dilution protocols, this assay can be used to estimate the concentration range of HSA simply by counting the number of bright spots. Our results show that the assay can detect HSA at concentrations as low as 15 μg mL−1. It is anticipated that this assay can provide a faster and simpler alternative for the diagnosis and prognosis of patients with kidney diseases.

Graphical abstract: Using liquid crystals as a readout system in urinary albumin assays

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Publication details

The article was received on 18 Feb 2011, accepted on 24 May 2011 and first published on 27 Jun 2011


Article type: Paper
DOI: 10.1039/C1AN15143F
Citation: Analyst, 2011,136, 3307-3313
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    Using liquid crystals as a readout system in urinary albumin assays

    V. J. Aliño and K. Yang, Analyst, 2011, 136, 3307
    DOI: 10.1039/C1AN15143F

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