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Issue 13, 2011
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Urine analysis in microfluidic devices

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Abstract

Microfluidics has attracted considerable attention since its early development in the 1980s and has experienced rapid growth in the past three decades due to advantages associated with miniaturization, integration and automation. Urine analysis is a common, fast and inexpensive clinical diagnostic tool in health care. In this article, we will be reviewing recent works starting from 2005 to the present for urine analysis using microfluidic devices or systems and to provide in-depth commentary about these techniques. Moreover, commercial strips that are often treated as chips and their readers for urine analysis will also be briefly discussed. We start with an introduction to the physiological significance of various components or measurement standards in urine analysis, followed by a brief introduction to enabling microfluidic technologies. Then, microfluidic devices or systems for sample pretreatments and for sensing urinary macromolecules, micromolecules, as well as multiplexed analysis are reviewed, in this sequence. Moreover, a microfluidic chip for urinary proteome profiling is also discussed, followed by a section discussing commercial products. Finally, the authors' perspectives on microfluidic-based urine analysis are provided. These advancements in microfluidic techniques for urine analysis may improve current routine clinical practices, particularly for point-of-care (POC) applications.

Graphical abstract: Urine analysis in microfluidic devices

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Publication details

The article was received on 11 Jan 2011, accepted on 15 May 2011 and first published on 27 May 2011


Article type: Critical Review
DOI: 10.1039/C1AN15029D
Citation: Analyst, 2011,136, 2669-2688
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    Urine analysis in microfluidic devices

    C. Lin, C. Tseng, T. Chuang, D. Lee and G. Lee, Analyst, 2011, 136, 2669
    DOI: 10.1039/C1AN15029D

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