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Issue 9, 2011
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Indicator approach to develop a chemosensor for the colorimetric sensing of thiol-containing water and its application for the thiol detection in plasma

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Abstract

A strategy for the determination of the presence of thiol-containing amino acids was successfully established by simply assembling copper chloride and xylenol orange (3,3′-bis[N,N-bis(carboxymethyl)aminomethyl]-o-cresolsulfonephthalein trisodium salt; XO) in a 1 : 1 molar ratio in quasi-physiological water solution (pH 6.0). The copper(II)XO ensemble was highly selective for thiol species such as cysteine, homocysteine, and glutathione without interference from other amino acids and could quantitatively detect thiol in the range from 10 to 200 μM with a linear relationship having an average molar absorbance constant of 6530 L mol −1 cm −1 in pure water. The whole recognition process for thiol gave rise to a rapid visual color change from purple-red to yellow which can be observed simultaneously with the naked-eye.

Graphical abstract: Indicator approach to develop a chemosensor for the colorimetric sensing of thiol-containing water and its application for the thiol detection in plasma

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Publication details

The article was received on 07 Jan 2011, accepted on 17 Feb 2011 and first published on 04 Mar 2011


Article type: Paper
DOI: 10.1039/C1AN15014F
Citation: Analyst, 2011,136, 1892-1897
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    Indicator approach to develop a chemosensor for the colorimetric sensing of thiol-containing water and its application for the thiol detection in plasma

    F. Huo, Y. Yang, J. Su, Y. Sun, C. Yin and X. Yan, Analyst, 2011, 136, 1892
    DOI: 10.1039/C1AN15014F

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