Molecular imaging and depth profiling by mass spectrometry—SIMS, MALDI or DESI?

John C. Vickerman

doi:10.1039/C1AN00008J

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Analyst

Issue 11, 2011

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Molecular imaging and depth profiling by mass spectrometry—SIMS, MALDI or DESI?

John C. Vickerman

Analyst, 2011, 136, 2199-2217

DOI: 10.1039/C1AN00008J
Received 04 Jan 2011, Accepted 23 Feb 2011
First published on the web 04 Apr 2011

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The possibility of exploiting the analytical power of mass spectrometry to image the chemistry of biological and similarly complex materials without the use of tags and with good spatial resolution is seductive. The status, strengths, weaknesses and complementarity of the three main techniques are briefly reviewed and assessed.

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Molecular imaging and depth profiling by mass spectrometry—SIMS, MALDI or DESI?

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