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Issue 10, 2011
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Electrochemical studies on the permeable characteristics of thiol-modified double-stranded DNA self-assembled monolayers on gold

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Abstract

In this article we studied the permeable characteristics of thiol-modified double-stranded DNA (ds-DNA) self-assembled monolayers (SAMs) on a gold substrate assembled under different NaCl concentrations by electrochemical methods. It was based on the inspection of five important parameters including interfacial capacitance (C), phase angle (Φ1 Hz), ions transfer resistance (Rit*), current density difference (Δj) and electron transfer rate (ket) through cyclic voltammetry (CV) and electrochemical impedance spectroscopy (EIS). Three sections were included: (1) Investigation of the relationships of C, Φ1 Hz, Rit*, Δj and ket with NaCl concentrations and comparison with the reports from literature. Experimental results showed that ds-DNA-SAMs were permeable films. (2) Construction of a simple model for exploring the permeable characteristics of ds-DNA-SAMs on gold. (3) Confirmation of the simple model by chronocoulometry (CC) and application of the model to explain the permeable mechanism. This study was significant for exploring the mechanism of electron transfer through the interior of ds-DNA duplex helix.

Graphical abstract: Electrochemical studies on the permeable characteristics of thiol-modified double-stranded DNA self-assembled monolayers on gold

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Publication details

The article was received on 22 Dec 2010, accepted on 15 Mar 2011 and first published on 12 Apr 2011


Article type: Paper
DOI: 10.1039/C0AN01032D
Citation: Analyst, 2011,136, 2090-2099
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    Electrochemical studies on the permeable characteristics of thiol-modified double-stranded DNA self-assembled monolayers on gold

    Z. Li, T. Niu, Z. Zhang, R. Chen, G. Feng and S. Bi, Analyst, 2011, 136, 2090
    DOI: 10.1039/C0AN01032D

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