Molecularly imprinted solid-phase extraction combined with ultrasound-assisted dispersive liquid–liquid microextraction for the determination of four Sudan dyes in sausage samples
Hongyuan
Yan
,
Jindong
Qiao
,
Hui
Wang
,
Gengliang
Yang
and
Kyung Ho
Row
Analyst, 2011, 136, 2629-2634
DOI:
10.1039/C0AN00951B
Received
26 Nov 2010,
Accepted
01 Apr 2011
First published on the web
10 May 2011
A simple and highly selective molecularly imprinted solid-phase extraction (MISPE) combined with ultrasound-assisted dispersive liquid-liquid microextraction (DLLME) was developed for the determination of four Sudan dye (I, II, III, and IV) residues in sausage products. The novel molecularly imprinted microspheres (MIMs) synthesized by aqueous suspension polymerization using phenylamine-naphthol as the dummy template show high affinity to the four Sudan dyes and were applied as selective sorbents of MISPE-DLLME to overcome the drawbacks of template leakage in quantitative analysis. Good linearity was obtained in a range of 0.005-2.0 µg g–1 and the average recoveries of the four Sudan dyes at three spiked levels ranged from 86.3 to 107.5%. The MISPE-DLLME-HPLC protocol significantly improved the purification and enrichment of the analytes and eliminated the template leakage of the conventional MISPE on quantitative analysis.
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