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Issue 6, 2011
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Continuous glucose monitoring by means of mid-infrared transmission laser spectroscopyin vitro

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Abstract

The continuous surveillance of glucose concentration reduces short-term risks and long-term complications for people with diabetes mellitus, a disorder of glucose metabolism. As a first step towards the continuous monitoring of glucose, reagent-free transmission spectroscopy in the mid-infrared region has been carried out in vitro using a quantum cascade laser and an optical silver halide fiber. A 30 μm gap in the fiber allowed for transmission spectroscopy of aqueous glucose solutions at a wavelength of 9.69 μm, which is specific to a molecular vibration of glucose. A noise-equivalent concentration as low as 4 mg/dL was achieved at an average power of 1.8 mW and an integration time of 50 s. This is among the most precise of glucose measurements using mid-infrared spectroscopy. Even with the very low average laser power of 0.07 mW the sensitivity of previous results (using a fiber optical evanescent field analysis) has been improved upon by almost one order of magnitude. Finally, the impact of potentially interfering substances such as other carbohydrates was analyzed.

Graphical abstract: Continuous glucose monitoring by means of mid-infrared transmission laser spectroscopyin vitro

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Publication details

The article was received on 17 Jul 2010, accepted on 21 Dec 2010 and first published on 27 Jan 2011


Article type: Paper
DOI: 10.1039/C0AN00537A
Citation: Analyst, 2011,136, 1192-1198
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    Continuous glucose monitoring by means of mid-infrared transmission laser spectroscopyin vitro

    C. Vrančić, A. Fomichova, N. Gretz, C. Herrmann, S. Neudecker, A. Pucci and W. Petrich, Analyst, 2011, 136, 1192
    DOI: 10.1039/C0AN00537A

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