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Issue 1, 2011
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A naked-eye visible and fluorescence “turn-on” probe for acetyl-cholinesterase assay and thiols as well as imaging of living cells

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Abstract

A resorufin derivative with a DBS group (probe 1) was designed and investigated for the detection of acetylcholinesterase (AChE) and inhibitor screening. The new assay is based on cascade enzymatic and chemical reactions of ATC, AChE and probe 1, and it can be carried out in a dual-signal detection mode. Moreover, the results show that probe 1 can be used for cell fluorescence staining.

Graphical abstract: A naked-eye visible and fluorescence “turn-on” probe for acetyl-cholinesterase assay and thiols as well as imaging of living cells

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Publication details

The article was received on 29 Jun 2010, accepted on 23 Aug 2010 and first published on 06 Oct 2010


Article type: Paper
DOI: 10.1039/C0AN00456A
Citation: Analyst, 2011,136, 191-195
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    A naked-eye visible and fluorescence “turn-on” probe for acetyl-cholinesterase assay and thiols as well as imaging of living cells

    K. Cui, Z. Chen, Z. Wang, G. Zhang and D. Zhang, Analyst, 2011, 136, 191
    DOI: 10.1039/C0AN00456A

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