Issue 5, 2010

Aromatic chloride to nitrile transformation: medicinal and synthetic chemistry

Abstract

This review highlights the medicinal and synthetic chemistry relevance of replacing an aromatic chloride motif with an aromatic nitrile. We explore the desirable features that this transformation can bring in a drug design sense and the recent synthetic chemistry advances that effect this replacement in a single step.

Graphical abstract: Aromatic chloride to nitrile transformation: medicinal and synthetic chemistry

Supplementary files

Article information

Article type
Review Article
Submitted
17 Aug 2010
Accepted
13 Sep 2010
First published
11 Oct 2010

Med. Chem. Commun., 2010,1, 309-318

Aromatic chloride to nitrile transformation: medicinal and synthetic chemistry

L. H. Jones, N. W. Summerhill, N. A. Swain and J. E. Mills, Med. Chem. Commun., 2010, 1, 309 DOI: 10.1039/C0MD00135J

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