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Issue 18, 2010
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Fabrication of engineered M13 bacteriophages into liquid crystalline films and fibers for directional growth and encapsulation of fibroblasts

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Abstract

We report on a novel method to utilize genetically engineered M13 phages as functional nano building blocks that can form structurally aligned film and fiber matrices for tissue engineering scaffolds. Two- and three-dimensional directionally aligned long range ordered structures were constructed using shearing and polyionic complexation with cationic polymers. Further we have demonstrated that aligned phage-based tissue engineering materials can guide and stimulate the growth of the target fibroblasts. Our phage-based tissue engineering scaffolds can be used for providing micro and macroscopic control of cell behaviors.

Graphical abstract: Fabrication of engineered M13 bacteriophages into liquid crystalline films and fibers for directional growth and encapsulation of fibroblasts

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Publication details

The article was received on 03 Apr 2010, accepted on 30 Jun 2010, published on 09 Aug 2010 and first published online on 09 Aug 2010


Article type: Paper
DOI: 10.1039/C0SM00199F
Citation: Soft Matter, 2010,6, 4454-4459
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    Fabrication of engineered M13 bacteriophages into liquid crystalline films and fibers for directional growth and encapsulation of fibroblasts

    W. Chung, A. Merzlyak and S. Lee, Soft Matter, 2010, 6, 4454
    DOI: 10.1039/C0SM00199F

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