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Issue 15, 2010
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Directed assembly of yeast cells into living yeastosomes by microbubble templating

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Abstract

We report the fabrication of yeastosomes—novel multicellular assemblies, which consist of a spherical monolayer of living yeast cells held together by colloid interactions. Our method is based on templating of microbubbles with cells coated with cationic polyelectrolyte and the layer-by-layer technique. We show the mechanism of formation of yeastosomes which involves a gradual dissolution of the air-cores and their infusion with water. We demonstrate that the cells remain viable in the yeastosome structures. Yeastosomes and similar structures may find applications in the development of novel symbiotic bio-structures, artificial multicellular organisms and in tissue engineering. The unusual structure of these multicellular assemblies resembles the primitive forms of multicellular species, like Volvox, and other algae and could be regarded as one possible stage of the evolutionary development of multicellularity.

Graphical abstract: Directed assembly of yeast cells into living yeastosomes by microbubble templating

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Publication details

The article was received on 18 Feb 2010, accepted on 01 Apr 2010 and first published on 17 May 2010


Article type: Paper
DOI: 10.1039/C0SM00003E
Citation: Soft Matter, 2010,6, 3494-3498
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    Directed assembly of yeast cells into living yeastosomes by microbubble templating

    M. Brandy, O. J. Cayre, R. F. Fakhrullin, O. D. Velev and V. N. Paunov, Soft Matter, 2010, 6, 3494
    DOI: 10.1039/C0SM00003E

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