Jump to main content
Jump to site search

Issue 11, 2010
Previous Article Next Article

Tunable hydrogel morphology via self-assembly of amphiphilic pentablock copolypeptides

Author affiliations

Abstract

Hydrogels assembled from symmetric amphiphilic pentablock copolypeptides were investigated using rheology and cryogenic transmission electron microscopy (cryoTEM). Due to the presence of two α-helical hydrophobic segments per chain, the pentablocks have the potential for organized intrachain folding, akin to natural proteins, in addition to intermolecular assembly. We found that variation of the central hydrophilic segment lengths in the copolymers enabled precise tuning of assembly morphology and hydrogel properties. CryoTEM characterization revealed that the hydrogels are nanoporous networks composed of branched and entangled tape-like fibrils, where average fibril length varied with the length of hydrophilic spacer between the hydrophobic domains. The pentablock architecture in these copolymers thus allowed additional control over self-assembled morphology and substantial enhancement of hydrogel properties.

Graphical abstract: Tunable hydrogel morphology via self-assembly of amphiphilic pentablock copolypeptides

Back to tab navigation

Supplementary files

Publication details

The article was received on 23 Dec 2009, accepted on 07 Apr 2010 and first published on 30 Apr 2010


Article type: Paper
DOI: 10.1039/B927137F
Citation: Soft Matter, 2010,6, 2546-2551
  •   Request permissions

    Tunable hydrogel morphology via self-assembly of amphiphilic pentablock copolypeptides

    Z. Li and T. J. Deming, Soft Matter, 2010, 6, 2546
    DOI: 10.1039/B927137F

Search articles by author

Spotlight

Advertisements