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Issue 5, 2010
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Neutron reflectometry of supported hybrid bilayers with inserted peptide

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Abstract

The insertion of a synthetic amphiphilic, α-helical peptide into a supported hybrid bilayer membrane (HBM) was studied by neutron reflectometry to elucidate the resulting nanostructure. The HBM consisted of a self-assembled monolayer of perdeuterated octadecanethiol on gold and an overlying leaflet of acyl-deuterated phosphatidylcholine (d-DMPC). Using contrast variation, several reflectivity spectra were recorded for each step of film fabrication, and simultaneously modeled. This analysis indicated that peptide insertion into the DMPC lipid leaflet is the likeliest mode of incorporation.

Graphical abstract: Neutron reflectometry of supported hybrid bilayers with inserted peptide

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Publication details

The article was received on 03 Aug 2009, accepted on 07 Dec 2009 and first published on 04 Jan 2010


Article type: Communication
DOI: 10.1039/B915800F
Citation: Soft Matter, 2010,6, 862-865
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    Neutron reflectometry of supported hybrid bilayers with inserted peptide

    M. B. Smith, D. J. McGillivray, J. Genzer, M. Lösche and P. K. Kilpatrick, Soft Matter, 2010, 6, 862
    DOI: 10.1039/B915800F

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