Jump to main content
Jump to site search

Issue 12, 2010
Previous Article Next Article

Salt-induced lipid transfer between colloidal supported lipid bilayers

Author affiliations

Abstract

We show that a coordinated interplay between mesoscale colloidal interactions and molecular-scale membrane perturbations affords a novel material platform to controllably recapitulate membrane interactions, such as during fusion and vesicle-based drug delivery. Specifically, a simple modulation of ionic strength is used to alter electrostatically determined colloidal interactions, producing conditions for pre-fusion contact between two independent colloidal and/or planar supported lipid bilayers. The same process also perturbs the membrane at the molecular level, reproducing conditions needed for subsequent fusion steps. We envisage that this platform will yield insights relevant to optimal design and implementation of lipid-coated inorganic constructs used for therapeutic drug delivery and sensing.

Graphical abstract: Salt-induced lipid transfer between colloidal supported lipid bilayers

Back to tab navigation

Supplementary files

Publication details

The article was received on 23 Jan 2010, accepted on 10 Mar 2010 and first published on 30 Mar 2010


Article type: Communication
DOI: 10.1039/C001586E
Citation: Soft Matter, 2010,6, 2628-2632
  •   Request permissions

    Salt-induced lipid transfer between colloidal supported lipid bilayers

    E. L. Kendall, E. Mills, J. Liu, X. Jiang, C. J. Brinker and A. N. Parikh, Soft Matter, 2010, 6, 2628
    DOI: 10.1039/C001586E

Search articles by author

Spotlight

Advertisements