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Issue 5, 2010
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Colloidal phytosterols: synthesis, characterization and bioaccessibility

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Abstract

We demonstrate the synthesis of phytosterol colloidal particles using a simple food grade method based on antisolvent precipitation in the presence of a non-ionic surfactant. The resulting colloidal particles have a rod-like shape with some degree of crystallinity. The colloidal dispersions display good stability assured by surface charge, due to the presence of water and hydroxyl groups on the particle surface, and by steric stabilisation, due to the presence of a non-ionic stabiliser. In vitro bioaccessibility experiments demonstrated that colloidal phytosterol can be effectively solubilised in model dietary mixed micelles and the micellar cholesterol concentration can be effectively reduced by 47% within two hours.

Graphical abstract: Colloidal phytosterols: synthesis, characterization and bioaccessibility

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Publication details

The article was received on 10 Jun 2009, accepted on 18 Nov 2009 and first published on 24 Dec 2009


Article type: Paper
DOI: 10.1039/B911371A
Citation: Soft Matter, 2010,6, 928-936
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    Colloidal phytosterols: synthesis, characterization and bioaccessibility

    L. Rossi, J. W. M. Seijen ten Hoorn, S. M. Melnikov and K. P. Velikov, Soft Matter, 2010, 6, 928
    DOI: 10.1039/B911371A

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