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Issue 8, 2010
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Elastomeric polypeptide-based biomaterials

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Abstract

Elastomeric proteins are characterized by their large extensibility before rupture, reversible deformation without loss of energy, and high resilience upon stretching. Motivated by their unique mechanical properties, there has been tremendous research in understanding and manipulating elastomeric polypeptides, with most work conducted on the elastins but more recent work on an expanded set of polypeptide elastomers. Facilitated by biosynthetic strategies, it has been possible to manipulate the physical properties, conformation, and mechanical properties of these materials. Detailed understanding of the roles and organization of the natural structural proteins has permitted the design of elastomeric materials with engineered properties, and has thus expanded the scope of applications from elucidation of the mechanisms of elasticity to the development of advanced drug delivery systems and tissue engineering substrates.

Graphical abstract: Elastomeric polypeptide-based biomaterials

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Publication details

The article was received on 09 Nov 2009, accepted on 03 Mar 2010 and first published on 02 Jun 2010


Article type: Review Article
DOI: 10.1039/B9PY00346K
Citation: Polym. Chem., 2010,1, 1160-1170
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    Elastomeric polypeptide-based biomaterials

    L. Li, M. B. Charati and K. L. Kiick, Polym. Chem., 2010, 1, 1160
    DOI: 10.1039/B9PY00346K

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