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Issue 4, 2010
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Vitamin D-fence

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Abstract

The role of vitamin D in the immune system is complex. Vitamin D is produced in the skin following exposure to ultraviolet radiation. There is compelling evidence that vitamin D compounds protect against ultraviolet radiation-induced DNA damage and immune suppression, suggesting it may be beneficial as a skin cancer preventive agent. However, vitamin D has many modulatory effects on the immune system and it has in fact been suggested that the immune suppression generally attributed to the UVB portion of sunlight is mediated through vitamin D. Here we describe the role of vitamin D compounds as “defence” molecules against UVR-induced damage, and investigate both sides of the “fence” regarding the effects of vitamin D compounds and the immune system.

Graphical abstract: Vitamin D-fence

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Publication details

The article was received on 02 Dec 2009, accepted on 08 Feb 2010 and first published on 03 Mar 2010


Article type: Perspective
DOI: 10.1039/B9PP00184K
Citation: Photochem. Photobiol. Sci., 2010,9, 564-570
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    Vitamin D-fence

    K. M. Dixon, V. B. Sequeira, A. J. Camp and R. S. Mason, Photochem. Photobiol. Sci., 2010, 9, 564
    DOI: 10.1039/B9PP00184K

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