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Issue 4, 2010
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In vitro measurements of sunscreen protection

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Abstract

The ultimate goal of in vitro measurements of sunscreen protection is replacement of invasive tests on human volunteer subjects. This requires validation of methods against a measurable in vivo benchmark, such as SPF. SPF is measured in the laboratory using artificial light sources that do not completely simulate sunlight. Once a method for in vitro measurements is validated, sunscreen protection against measured solar spectra may be achieved. Critical aspects of in vitro measurements of sun protection include the ability of substrates to emulate human skin, performance of instrumentation and use of correct algorithms to account for changes in sunscreen absorbance during irradiation. We have developed a dose–response model that accounts for changes in absorbance and facilitates evaluation of broad spectrum protection, as well as SPF, and provides an index of sunscreen photostability.

Graphical abstract: In vitro measurements of sunscreen protection

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Publication details

The article was received on 01 Dec 2009, accepted on 24 Feb 2010 and first published on 15 Mar 2010


Article type: Perspective
DOI: 10.1039/B9PP00181F
Citation: Photochem. Photobiol. Sci., 2010,9, 489-494
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    In vitro measurements of sunscreen protection

    J. Stanfield, U. Osterwalder and B. Herzog, Photochem. Photobiol. Sci., 2010, 9, 489
    DOI: 10.1039/B9PP00181F

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