Issue 4, 2010
From the journal:

Photochemical & Photobiological Sciences

Dietary glucoraphanin-rich broccoli sprout extracts protect against UV radiation-induced skin carcinogenesis in SKH-1 hairless mice

Albena T. Dinkova-Kostova,*ac   Jed W. Fahey,ab   Andrea L. Benedict,a   Stephanie N. Jenkins,a   Lingxiang Ye,a   Scott L. Wehagea  and  Paul Talalaya  

* Corresponding authors

a The Lewis B. and Dorothy Cullman Cancer Chemoprotection Center, Department of Pharmacology and Molecular Sciences, School of Medicine, Johns Hopkins University, Baltimore, Maryland, USA

b Center for Human Nutrition, School of Public Health, Johns Hopkins University, Baltimore, Maryland, USA

c The Biomedical Research Institute, University of Dundee, Dundee, Scotland, United Kingdom
E-mail: a.dinkovakostova@dundee.ac.uk
Fax: +44 (0)1382 669993
Tel: +44 (0)1382 740045

Abstract

Feeding broccoli sprout extracts providing daily doses of 10 μmol of glucoraphanin to SKH-1 hairless mice with prior chronic exposure to UV radiation (30 mJ cm−2 of UVB, twice a week, for 17 weeks) inhibited the development of skin tumors during the subsequent 13 weeks; compared to the controls, tumor incidence, multiplicity, and volume were reduced by 25, 47, and 70%, respectively, in the animals that received the protective agent.

Graphical abstract: Dietary glucoraphanin-rich broccoli sprout extracts protect against UV radiation-induced skin carcinogenesis in SKH-1 hairless mice

About
Cited by
Related
Download options Please wait...

Article information

DOI
https://doi.org/10.1039/B9PP00130A
Article type
Communication
Submitted
12 Oct 2009
Accepted
13 Dec 2009
First published
28 Jan 2010

Photochem. Photobiol. Sci., 2010,9, 597-600

Permissions

Request permissions

Dietary glucoraphanin-rich broccoli sprout extracts protect against UV radiation-induced skin carcinogenesis in SKH-1 hairless mice

A. T. Dinkova-Kostova, J. W. Fahey, A. L. Benedict, S. N. Jenkins, L. Ye, S. L. Wehage and P. Talalay, Photochem. Photobiol. Sci., 2010, 9, 597 DOI: 10.1039/B9PP00130A

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Spotlight

Advertisements