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Issue 4, 2010
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Dietary glucoraphanin-rich broccoli sprout extracts protect against UV radiation-induced skin carcinogenesis in SKH-1 hairless mice

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Abstract

Feeding broccoli sprout extracts providing daily doses of 10 μmol of glucoraphanin to SKH-1 hairless mice with prior chronic exposure to UV radiation (30 mJ cm−2 of UVB, twice a week, for 17 weeks) inhibited the development of skin tumors during the subsequent 13 weeks; compared to the controls, tumor incidence, multiplicity, and volume were reduced by 25, 47, and 70%, respectively, in the animals that received the protective agent.

Graphical abstract: Dietary glucoraphanin-rich broccoli sprout extracts protect against UV radiation-induced skin carcinogenesis in SKH-1 hairless mice

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Publication details

The article was received on 12 Oct 2009, accepted on 13 Dec 2009 and first published on 28 Jan 2010


Article type: Communication
DOI: 10.1039/B9PP00130A
Citation: Photochem. Photobiol. Sci., 2010,9, 597-600
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    Dietary glucoraphanin-rich broccoli sprout extracts protect against UV radiation-induced skin carcinogenesis in SKH-1 hairless mice

    A. T. Dinkova-Kostova, J. W. Fahey, A. L. Benedict, S. N. Jenkins, L. Ye, S. L. Wehage and P. Talalay, Photochem. Photobiol. Sci., 2010, 9, 597
    DOI: 10.1039/B9PP00130A

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