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Issue 22, 2010
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Access to phosphoproteins and glycoproteins through semi-synthesis, Native Chemical Ligation and NS acyl transfer

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Abstract

Peptide thioesters are important tools for protein synthesis and semi-synthesis through their use in Native Chemical Ligation (NCL). NCL can be employed to assemble site-specifically modified proteins that can help elucidate the mechanisms of biomolecular processes. In this article we explore the compatibility of phosphopeptide synthesis and glycopeptide synthesis with thioester production through NS acyl transfer.

Graphical abstract: Access to phosphoproteins and glycoproteins through semi-synthesis, Native Chemical Ligation and N→S acyl transfer

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Publication details

The article was received on 30 Jun 2010, accepted on 09 Aug 2010 and first published on 09 Sep 2010


Article type: Paper
DOI: 10.1039/C0OB00363H
Citation: Org. Biomol. Chem., 2010,8, 5113-5119
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    Access to phosphoproteins and glycoproteins through semi-synthesis, Native Chemical Ligation and NS acyl transfer

    J. Masania, J. Li, S. J. Smerdon and D. Macmillan, Org. Biomol. Chem., 2010, 8, 5113
    DOI: 10.1039/C0OB00363H

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