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Issue 17, 2010
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Delineating the earliest steps of gilvocarcin biosynthesis: role of GilP and GilQ in starter unit specificity

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Abstract

In vivo and in vitro investigations of GilP and GilQ, two acyltransferases encoded by the gilvocarcin gene cluster, show that GilQ confers unique starter unit specificity when catalyzing an early as well as rate limiting step of gilvocarcin biosynthesis.

Graphical abstract: Delineating the earliest steps of gilvocarcin biosynthesis: role of GilP and GilQ in starter unit specificity

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Publication details

The article was received on 22 Apr 2010, accepted on 23 Jun 2010 and first published on 08 Jul 2010


Article type: Communication
DOI: 10.1039/C0OB00036A
Citation: Org. Biomol. Chem., 2010,8, 3851-3856
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    Delineating the earliest steps of gilvocarcin biosynthesis: role of GilP and GilQ in starter unit specificity

    M. D. Shepherd, M. K. Kharel, L. L. Zhu, S. G. van Lanen and J. Rohr, Org. Biomol. Chem., 2010, 8, 3851
    DOI: 10.1039/C0OB00036A

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