Jump to main content
Jump to site search

Issue 17, 2010
Previous Article Next Article

Expeditious synthesis and biological evaluation of new C-6 1,2,3-triazole adenosine derivatives A1 receptor antagonists or agonists

Author affiliations

Abstract

The synthesis of new C-6 1,2,3-triazole adenosine derivatives via microwave assisted 1,3-dipolar cycloaddition as key step is described. The binding on membranes of cells that over express A1 adenosine receptors (A1AR) was also evaluated. Among them, four compounds increased cAMP production, in a dose-dependent manner acting as antagonists of the A1AR, while two compounds act as agonists.

Graphical abstract: Expeditious synthesis and biological evaluation of new C-6 1,2,3-triazole adenosine derivatives A1 receptor antagonists or agonists

Back to tab navigation

Supplementary files

Publication details

The article was received on 19 Apr 2010, accepted on 11 Jun 2010 and first published on 09 Jul 2010


Article type: Paper
DOI: 10.1039/C0OB00017E
Citation: Org. Biomol. Chem., 2010,8, 3874-3881
  •   Request permissions

    Expeditious synthesis and biological evaluation of new C-6 1,2,3-triazole adenosine derivatives A1 receptor antagonists or agonists

    S. C. Mathew, Y. By, A. Berthault, M. Virolleaud, L. Carrega, G. Chouraqui, L. Commeiras, J. Condo, M. Attolini, A. Gaudel-Siri, J. Ruf, J. Rodriguez, J. Parrain and R. Guieu, Org. Biomol. Chem., 2010, 8, 3874
    DOI: 10.1039/C0OB00017E

Search articles by author

Spotlight

Advertisements