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Issue 12, 2010
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Tuned methods for conjugate addition to a vinyl oxadiazole; synthesis of pharmaceutically important motifs

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Abstract

The addition of various nucleophiles to a vinyl 1,2,4-oxadiazole is described. Following optimisation, individual protocols tuned for the use of each specific class of reagent have been developed to allow the installation of nitrogen, sulfur, oxygen, and carbon nucleophiles, and leading to the preparation of a series of compounds containing the pharmaceutically important oxadiazole motif.

Graphical abstract: Tuned methods for conjugate addition to a vinyl oxadiazole; synthesis of pharmaceutically important motifs

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Publication details

The article was received on 26 Jan 2010, accepted on 25 Mar 2010 and first published on 28 Apr 2010


Article type: Paper
DOI: 10.1039/C001772H
Citation: Org. Biomol. Chem., 2010,8, 2777-2783
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    Tuned methods for conjugate addition to a vinyl oxadiazole; synthesis of pharmaceutically important motifs

    A. R. Burns, J. H. Kerr, W. J. Kerr, J. Passmore, L. C. Paterson and A. J. B. Watson, Org. Biomol. Chem., 2010, 8, 2777
    DOI: 10.1039/C001772H

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