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Issue 9, 2010
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Reagent based DOS: A “Click, Click, Cyclize” strategy to probe chemical space

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Abstract

The synthesis of small organic molecules as probes for discovering new therapeutic agents has been an important aspect of chemical-biology. Herein we report a reagent-based, diversity-oriented synthetic (DOS) strategy to probe chemical and biological space via a “Click, Click, Cyclize” protocol. In this DOS approach, three sulfonamide linchpins underwent cyclization protocols with a variety of reagents to yield a collection of structurally diverse S-heterocycles. In silico analysis is utilized to evaluate the diversity of the compound collection against chemical space (PC analysis), shape space (PMI) and polar surface area (PSA) calculations.

Graphical abstract: Reagent based DOS: A “Click, Click, Cyclize” strategy to probe chemical space

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Publication details

The article was received on 05 Jan 2010, accepted on 15 Feb 2010 and first published on 16 Mar 2010


Article type: Paper
DOI: 10.1039/B927161A
Citation: Org. Biomol. Chem., 2010,8, 2198-2203
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    Reagent based DOS: A “Click, Click, Cyclize” strategy to probe chemical space

    A. Rolfe, Gerald. H. Lushington and Paul. R. Hanson, Org. Biomol. Chem., 2010, 8, 2198
    DOI: 10.1039/B927161A

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