The application of flow microreactors to the preparation of a family of casein kinase I inhibitors

Francesco Venturoni; Nikzad Nikbin; Steven V. Ley; Ian R. Baxendale

doi:10.1039/B925327K

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Organic & Biomolecular Chemistry

Issue 8, 2010

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The application of flow microreactors to the preparation of a family of casein kinase I inhibitors

Francesco Venturoni , Nikzad Nikbin , Steven V. Ley and Ian R. Baxendale

Org. Biomol. Chem., 2010, 8, 1798-1806

DOI: 10.1039/B925327K
Received 02 Dec 2009, Accepted 18 Jan 2010
First published on the web 17 Feb 2010
This article is part of the collection: Enabling Technologies for Organic Synthesis

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Abstract
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In this article we demonstrate how a combination of enabling technologies such as flow synthesis, solid-supported reagents and scavenging resins utilised under fully automated software control can assist in typical medicinal chemistry programmes. In particular automated continuous flow methods have greatly assisted in the optimisation of reaction conditions and facilitated scale up operations involving hazardous chemical materials. Overall a collection of twenty diverse analogues of a casein kinase I inhibitor has been synthesised by changing three principle binding vectors.

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Organic & Biomolecular Chemistry

The application of flow microreactors to the preparation of a family of casein kinase I inhibitors

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