Jump to main content
Jump to site search

Issue 9, 2010
Previous Article Next Article

Peptide and protein thioester synthesis via N→S acyl transfer

Author affiliations

Abstract

Peptide and protein thioesters are playing an increasingly prominent role in the chemical toolbox for protein assembly and modification through Native Chemical Ligation (NCL). In this Emerging Area we highlight recent developments in a somewhat surprising route to thioesters: selective disruption of amides, the more stable carboxylic acid derivatives.

Graphical abstract: Peptide and protein thioester synthesis via N→S acyl transfer

Back to tab navigation

Publication details

The article was received on 30 Nov 2009, accepted on 29 Jan 2010 and first published on 18 Feb 2010


Article type: Emerging Area
DOI: 10.1039/B925075A
Citation: Org. Biomol. Chem., 2010,8, 1993-2002
  •   Request permissions

    Peptide and protein thioester synthesis via N→S acyl transfer

    J. Kang and D. Macmillan, Org. Biomol. Chem., 2010, 8, 1993
    DOI: 10.1039/B925075A

Search articles by author

Spotlight

Advertisements