Rapid two-step synthesis of drug-like polycyclic substances by sequential multi-catalysis cascade reactions

Dhevalapally B. Ramachary; Rumpa Mondal; Chintalapudi Venkaiah

doi:10.1039/B920152A

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Organic & Biomolecular Chemistry

Issue 2, 2010

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Rapid two-step synthesis of drug-like polycyclic substances by sequential multi-catalysis cascade reactions

Dhevalapally B. Ramachary , Rumpa Mondal and Chintalapudi Venkaiah

Org. Biomol. Chem., 2010, 8, 321-325

DOI: 10.1039/B920152A
Received 28 Sep 2009, Accepted 19 Oct 2009
First published on the web 28 Oct 2009

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Abstract
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An efficient amino acid-/self-/base-/ruthenium-/thermal-catalyzed two-step process for the synthesis of functionalized drug-like carbocycles was achieved through combinations of cascade TCRA/C-allylation/enyne-RCM/Diels–Alder reactions as key steps starting from simple acyclic substrates. In this communication, we report the two-step synthesis of drug-like carbocycles through a combination of organocatalysis with ruthenium-catalysis.

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Experimental procedures and analytical data ( ¹H NMR, ¹³C NMR and HRMS) for all new compounds
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Organic & Biomolecular Chemistry

Rapid two-step synthesis of drug-like polycyclic substances by sequential multi-catalysis cascade reactions

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